Vic Darchinyan started to fight professionally at the age of 24, winning his first fight over Sande Kizito in 2000. This paved the way for 27 more fights, 22 of which he won. It was in 2004 that he won his first match in the US by defeating Irene Pacheco in the 11th round. In 2007, he also defeated Glenn Donaire and Victor Burgos, sending the latter to surgery to have a blood clot removed after their bout.

However, Darchinyan later lost to Nonito Donaire, Glenn Donaire's brother by TKO in the fifth round in the same year. After losing his flyweight belts to Donaire, he moved up to the super flyweight division and won the IBO and IBF belts with his victory of Federico Catubay. He later took on Dimitri Kirilov in 2008, knocking the opponent in the fifth round in Washington.

Super-bantamweight

Darchinyan moved up in weight class afterwards and, on 29 September 2012, defeated Luis Del Valle to win the vacant NABF super bantamweight title.

A rematch between Vic Darchinyan and Nonito Donaire took place on 9 November 2013. The 37 year old Darchinyan gave the 30 year old Donaire a lot more trouble than was expected, as this was intended to be an easy bounce-back fight for Donaire who was coming off his first loss in over a decade. Darchinyan fought a smarter fight and confused a sluggish Donaire for much of the first 8 rounds, but in the 9th round was dropped and got up to be finished by TKO. At the time of the stoppage, Darchinyan was leading on the scorecards: 78-74, 78-74, and 76-76.

Featherweight

Afterwards, Darchinyan fought up another weight class and challenged Nicholas Walters for his WBA featherweight title on 31 May 2014 in Macau. The fight went five rounds before Darchinyan was knocked out. Darchinyan won his next fight against Juan Jimenez by TKO in the 9th round. The bout took place on 7 February 2015 in Mexico, the seventh country Darchinyan had fought in. He fought WBA (Regular) featherweight titleholder Jesus Cuellar on 6 June 2015 by winning the vacant WBC-ABCO super bantamweight title.

In 2016, he was knocked out in two rounds by journeyman Sergio Frias and did not fight again that year.

After taking some time off to re-evaluate, Darchinyan knocked out Pakpoom Hammarach in one round on 10 March 2017. The fight was taken by Darchinyan not for the money, but to see if he still had the hunger and desire to continue his boxing career. Taking place in Perth, this would be his last fight in Australia. He has confirmed his next fight will be his last and expressed interest in one more big fight against Evgeny Gradovich in Russia or Carl Frampton in England.

Outside boxing

On 21 September 2008, Darchinyan and fellow boxer Arthur Abraham were honored by Armenian President Serge Sargsyan during a 20th anniversary celebration of the nation's independence. Both men were awarded with medals "For the great services for Armenia" of the first degree.